Recently, adipose-derived mesenchymal stem cells (ASCs) have been paid more attention for cartilage regeneration. This new product evaluated the use of ASCs seeded as pre-chondrocyts in a three dimensional matrix. Therefore transforming growth factor beta TGF-activated three-dimensional hydrogel scaffolds is used for improving cartilage repair in vivo. Transforming growth factor beta-activated scaffolds showed high collagen type II and aggrecan expression and low collagen type I expression during in vitro cultivation.
ASC-based pTGF-beta1-activated scaffolds also exhibited cartilage histology with high secretion of collagen type II in vitro under the stimulation of pTGF-beta1. In dogs with full-thickness cartilage defects, the injection of ASC-based pTGF-beta-activated scaffolds not only significantly promoted chondrogenic differentiation of ASCs and hyalin-like cartilage matrix synthesis, but also remarkably improved the overall repair of joint defects and exhibited favorable tissue integrity at 10 weeks post injection. These results suggest that MSC-based localized pTGF-beta1-activated scaffolds have potential applications for in vivo cartilage repair.
The product Dog-Stem grade IV refers to severe cases of cartilage defects. In attachment you find some more information on this product.
For orders , you can contact us ( firstname.lastname@example.org) , a kit for a biopsy will be sent and we will collect it at your reception. You pay only after receiving /injection of the product.
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